巴黎人网站_巴黎人捕鱼_巴黎人现金网

最新公告:

欢迎光临本公司网站!
搜狐新闻
新浪新闻
新闻报刊

地址:广东省广州市天河区88号

电话:13988999988

传真:+86-123-4567

热线:400-123-4567

邮箱:admin@baidu.com

当前位置:主页 > 凤凰资讯 >

多种酶活性参与介导原核生物的抗病毒免疫

文章来源: 更新时间:2020-08-31 19:46

本期文章:《科学》:Volume 369 Issue 6507

美国麻省理工学院张锋实验室发现多种酶活性参与介导原核生物的抗病毒免疫。相关论文发表在2020年8月28日出版的《科学》杂志上。

通过系统的防御基因预测和异源重组,研究人员发现了29种广泛的抗病毒基因盒,其共同存在于32%的所有已测序细菌和古细菌基因组中,它们介导了针对特定噬菌体的保护。这些系统结合了以往未知的抗病毒防御酶活,包括RNA编辑和卫星DNA合成逆转录。此外,研究人员通过计算预测了仍有待鉴定的其他潜在防御基因。这些结果突出了微生物用来抵御病毒的大量分子功能。

据介绍,细菌和古细菌经常受到病毒和其他移动遗传元件的攻击,并依靠专用的抗病毒防御系统(如限制性内切核酸酶和CRISPR)来生存。病毒种类繁多,这表明防御系统的类型比目前已知的要多。 

附:英文原文

Title: Diverse enzymatic activities mediate antiviral immunity in prokaryotes

Author: Linyi Gao, Han Altae-Tran, Francisca Bhning, Kira S. Makarova, Michael Segel, Jonathan L. Schmid-Burgk, Jeremy Koob, Yuri I. Wolf, Eugene V. Koonin, Feng Zhang

Issue&Volume: 2020/08/28

Abstract: Bacteria and archaea are frequently attacked by viruses and other mobile genetic elements and rely on dedicated antiviral defense systems, such as restriction endonucleases and CRISPR, to survive. The enormous diversity of viruses suggests that more types of defense systems exist than are currently known. By systematic defense gene prediction and heterologous reconstitution, here we discover 29 widespread antiviral gene cassettes, collectively present in 32% of all sequenced bacterial and archaeal genomes, that mediate protection against specific bacteriophages. These systems incorporate enzymatic activities not previously implicated in antiviral defense, including RNA editing and retron satellite DNA synthesis. In addition, we computationally predict a diverse set of other putative defense genes that remain to be characterized. These results highlight an immense array of molecular functions that microbes use against viruses.

DOI: 10.1126/science.aba0372

Source: https://science.sciencemag.org/content/369/6507/1077

期刊信息

Science:《科学》,创刊于1880年。隶属于美国科学促进会,最新IF:41.037

官方网址:https://www.sciencemag.org/

地址:广东省广州市天河区88号电话:400-123-4567传真:+86-123-4567

Copyright © 2002-2019 巴黎人网站 版权所有 Power by DeDe58技术支持:百度 ICP备案编号:ICP备********号